Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 14/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27621412 | 0.81 | ELANE (0.40) | ELANEMAPT | |
| SCHEMBL27808009 | 0.80 | ELANE (0.39) | ELANECA2MAPT | |
| SCHEMBL27805740 | 0.80 | ELANE (0.39) | ELANEMAPT | |
| SCHEMBL27621546 | 0.80 | ELANE (0.37) | ELANEHTR1DHTR1B | |
| SCHEMBL27791447 | 0.78 | SLC22A12 (0.36) | ELANEMAPT | |
| SCHEMBL27594623 | 0.77 | ELANE (0.35) | ELANEHTR1DHTR1B | |
| SCHEMBL28046986 | 0.76 | ELANE (0.37) | ELANEHTR1DHTR1B | |
| SCHEMBL27805639 | 0.76 | ELANE (0.36) | ELANE | |
| SCHEMBL27786236 | 0.76 | MAPT (0.43) | ELANEMAPT | |
| SCHEMBL28127386 | 0.75 | ELANE (0.36) | ELANEHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164121-A | Perfluorinated cyclopropyl-fused 1, 3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use thereof | AMGEN INC | 2015-12-16 | — | — | CN | disclosed |