Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphonic Acid SCHEMBL28048733 | 0.97 | THRB (0.46) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL33780 | 0.89 | THRB (0.52) | THRBTSHRALDH1A1POLBAPEX1 | |
| Acetic Acid SCHEMBL28158415 | 0.86 | THRB (0.48) | THRBTSHRALDH1A1POLBAPEX1 | |
| Methacrylic Acid SCHEMBL9453881 | 0.84 | THRB (0.47) | THRBTSHRALDH1A1POLBAPEX1 | |
| Cyanamide SCHEMBL28026068 | 0.84 | THRB (0.47) | THRBTSHRALDH1A1POLBAPEX1 | |
| Methacrylic Acid SCHEMBL10424224 | 0.84 | THRB (0.47) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL10433862 | 0.83 | THRB (0.55) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL28134507 | 0.83 | THRB (0.46) | THRBTSHRALDH1A1POLBAPEX1 | |
| Carbamic Acid SCHEMBL28329175 | 0.83 | THRB (0.46) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL28039568 | 0.81 | THRB (0.44) | THRBTSHRALDH1A1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105392488-A | Compositions and methods for modulating apolipoprotein c-iii expression | ISIS PHARMACEUTICALS INC | 2016-03-09 | — | — | CN | disclosed |
| CN-105378085-A | Compositions and methods for modulating HBV and TTR expression | ISIS PHARMACEUTICALS INC | 2016-03-02 | — | — | CN | disclosed |
| CN-105378082-A | Compositions and methods | ISIS PHARMACEUTICALS INC | 2016-03-02 | — | — | CN | disclosed |
| CN-105377887-A | Compositions and methods for modulating apolipoprotein (a) expression | ISIS PHARMACEUTICALS INC | 2016-03-02 | — | — | CN | disclosed |