Diphenylacetylene

Diphenylacetylene

SCHEMBL28827583

C(#Cc1ccccc1)c1ccccc1.CCCCCN=C=S

nearest known ligand 0.60

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Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NAAA Q02083 7/20 0.60
MIF P14174 4/20 0.54
MAOA P21397 1/20 0.48
MAOB P27338 1/20 0.48
KEAP1 Q14145 7/20 0.47
NFE2L2 Q16236 7/20 0.47
TRPA1 O75762 1/20 0.46
CYP2E1 P05181 1/20 0.46
CYP2A6 P11509 1/20 0.46
HIF1A Q16665 1/20 0.46
CYP2A13 Q16696 1/20 0.46
EPAS1 Q99814 1/20 0.46
APP P05067 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butyl Isothiocyanate SCHEMBL28049419 0.79 NAAA (0.70) NAAAMIFMAOAMAOBKEAP1
1-Isothiocyanatopentane SCHEMBL175645 0.79
1-Isothiocyanatooctane SCHEMBL331051 0.77 NAAA (1.00) NAAAMIFKEAP1NFE2L2TRPA1
SCHEMBL9831163 0.77 NAAA (1.00) NAAAMIFKEAP1NFE2L2TRPA1
1-Isothiocyanatopentane SCHEMBL8007293 0.77
SCHEMBL10822521 0.77 NAAA (1.00) NAAAMIFKEAP1NFE2L2TRPA1
1-Isothiocyanatoheptane SCHEMBL330703 0.77 NAAA (1.00) NAAAMIFKEAP1NFE2L2TRPA1
SCHEMBL330890 0.77 NAAA (1.00) NAAAMIFKEAP1NFE2L2TRPA1
SCHEMBL1457042 0.77 NAAA (1.00) NAAAMIFKEAP1NFE2L2TRPA1
SCHEMBL331790 0.77 NAAA (1.00) NAAAMIFKEAP1NFE2L2TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108431174-B Birefringent liquid crystal compositions comprising alkylsulfanyl aryl isothiocyanatodiphenylacetylene compounds 依视路国际公司 2022-08-26 CN disclosed