SCHEMBL28828658

SCHEMBL28828658

CCOc1ccc(-c2cc3c(cc2F)C(OC(N)=O)C(C)(C)C3)cc1F

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 2/20 0.36
FFAR4 Q5NUL3 13/20 0.35
NAAA Q02083 1/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
MAPT P10636 1/20 0.34
HTT P42858 1/20 0.34
PRKCZ Q05513 1/20 0.34
CSF1R P07333 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29121308 1.00 KDM1A (0.36) KDM1AFFAR4NAAAKDM4EALDH1A1
SCHEMBL29121350 0.92 FFAR4 (0.37) KDM1AFFAR4KDM4EALDH1A1MAPT
SCHEMBL29121266 0.92 BTK (0.37) FFAR4MAPT
SCHEMBL29121298 0.92 FFAR4 (0.38) FFAR4KDM4EALDH1A1MAPTHTT
SCHEMBL27212739 0.92 PRKCZ (0.38) KDM1AFFAR4PRKCZ
SCHEMBL29121280 0.89 AR (0.42) NAAAHTTPRKCZ
SCHEMBL29121339 0.89 KDM1A (0.38) KDM1AFFAR4NAAAKDM4EALDH1A1
SCHEMBL28828503 0.89 KDM1A (0.38) KDM1AFFAR4NAAAKDM4EALDH1A1
SCHEMBL28828397 0.88 FFAR4 (0.43) FFAR4ALDH1A1MAPT
SCHEMBL29121251 0.88 FFAR4 (0.43) FFAR4ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114829361-B Derivatives having 2, 3-dihydro-1H-indene or 2, 3-dihydrobenzofuran moiety or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same 柳韩洋行 2024-07-16 CN claimed
CN-114829361-A Derivatives having 2, 3-dihydro-1H-indene or 2, 3-dihydrobenzofuran moiety or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing same 柳韩洋行 2022-07-29 CN claimed
CN-114829361-B Derivatives having 2, 3-dihydro-1H-indene or 2, 3-dihydrobenzofuran moiety or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same 柳韩洋行 2024-07-16 CN disclosed
CN-114829361-A Derivatives having 2, 3-dihydro-1H-indene or 2, 3-dihydrobenzofuran moiety or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing same 柳韩洋行 2022-07-29 CN disclosed