SCHEMBL28829068

SCHEMBL28829068

O=c1[nH]c(Br)c(-c2ccc(Cl)cc2)n1CC(O)C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AVPR2 P30518 20/20 0.41
AVPR1A P37288 20/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28829065 1.00 AVPR2 (0.41) AVPR2AVPR1A
SCHEMBL28828769 0.87 AVPR2 (0.42) AVPR2AVPR1A
SCHEMBL28828770 0.87 AVPR2 (0.42) AVPR2AVPR1A
SCHEMBL28828912 0.85 AVPR2 (0.43) AVPR2AVPR1A
SCHEMBL28828920 0.85 AVPR2 (0.43) AVPR2AVPR1A
SCHEMBL28829055 0.79 GRIN1 (0.38) AVPR2AVPR1A
SCHEMBL28828872 0.75 POLB (0.44)
SCHEMBL28828981 0.74 AVPR2 (0.41) AVPR2AVPR1A
SCHEMBL28828985 0.74 AVPR2 (0.41) AVPR2AVPR1A
SCHEMBL256612 0.73 AVPR2 (0.51) AVPR2AVPR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114835688-A Substituted 4-aryl imidazole-2-ketone derivative and preparation method and medical application thereof 深圳信立泰药业股份有限公司 2022-08-02 CN disclosed