Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.66 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.66 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | RAD52 | P43351 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 2/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.48 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL27652869 | 0.94 | FFAR1 (0.63) | FFAR1FFAR4GPR84NFKB1PSMD14 | |
| Acetic Acid SCHEMBL1171378 | 0.94 | FFAR1 (0.63) | FFAR1FFAR4GPR84NFKB1PSMD14 | |
| Acetic Acid SCHEMBL3205436 | 0.92 | FFAR1 (0.60) | FFAR1FFAR4GPR84NFKB1PSMD14 | |
| SCHEMBL16074935 | 0.91 | FFAR4 (0.57) | FFAR1FFAR4GPR84NFKB1PSMD14 | |
| SCHEMBL21660117 | 0.91 | FFAR4 (0.57) | FFAR1FFAR4GPR84NFKB1PSMD14 | |
| SCHEMBL23188459 | 0.91 | FFAR4 (0.57) | FFAR1FFAR4GPR84NFKB1PSMD14 | |
| SCHEMBL887247 | 0.91 | FFAR4 (0.57) | FFAR1FFAR4GPR84NFKB1PSMD14 | |
| SCHEMBL22910843 | 0.91 | FFAR4 (0.57) | FFAR1FFAR4GPR84NFKB1PSMD14 | |
| SCHEMBL19949219 | 0.91 | FFAR4 (0.57) | FFAR1FFAR4GPR84NFKB1PSMD14 | |
| SCHEMBL7209288 | 0.91 | FFAR4 (0.57) | FFAR1FFAR4GPR84NFKB1PSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110167995-B | Plasticized PVC compounds having surface-modified macromolecules and articles made therefrom | 界面生物公司 | 2022-07-01 | — | — | CN | disclosed |