SCHEMBL28829231

SCHEMBL28829231

CC(C)(Oc1ccc(Cl)cc1)C(=O)NC1C2CC3CC1CC(CC/C=C/C(=O)O)(C3)C2

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 20/20 0.75
HSD11B2 P80365 12/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1045625 0.86 HSD11B1 (1.00) HSD11B1HSD11B2
SCHEMBL1044874 0.84 HSD11B1 (1.00) HSD11B1HSD11B2
SCHEMBL1046310 0.84 HSD11B1 (1.00) HSD11B1HSD11B2
SCHEMBL1043181 0.82 HSD11B1 (0.71) HSD11B1HSD11B2
SCHEMBL1043184 0.82 HSD11B1 (0.71) HSD11B1HSD11B2
SCHEMBL1045505 0.81 HSD11B1 (0.83) HSD11B1HSD11B2
SCHEMBL27966091 0.81 HSD11B1 (0.80) HSD11B1HSD11B2
SCHEMBL1045126 0.81 HSD11B1 (0.82) HSD11B1HSD11B2
SCHEMBL2462504 0.81 HSD11B1 (0.78) HSD11B1HSD11B2
SCHEMBL1042186 0.81 HSD11B1 (0.78) HSD11B1HSD11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103242192-B The inhibitor of 11-beta-hydroxysteroid dehydrogenase 1 type enzyme ABBVIE INC. (US) 2016-05-04 CN disclosed