Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 10/20 | 0.52 |
| ▸ | GIPR | P48546 | 3/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2881085 | 0.92 | GCGR (0.49) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2883051 | 0.89 | GCGR (0.67) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2883978 | 0.88 | GCGR (0.52) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2666819 | 0.86 | GCGR (0.46) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2883860 | 0.86 | GCGR (0.51) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL4392209 | 0.82 | FLT1 (0.44) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2884259 | 0.76 | MEN1 (0.55) | HDAC1ALDH1A1GAASMN1; SMN2MAPT | |
| SCHEMBL9071146 | 0.76 | NPSR1 (0.41) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2885559 | 0.73 | PTGDR2 (0.49) | GCGRGIPRPTGER4HDAC1ALDH1A1 | |
| SCHEMBL2883065 | 0.73 | PTGDR2 (0.49) | GCGRGIPRPTGER4HDAC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7649009-B2 | N-(trans-4-tert-butylcyclohexyl)-1-{4-[(1h-tetrazol-5-ylamino)carbonyl]benzyl }-3-(3,4,5-trifluoropbenyl)-1h-pyrazole-5-carboxamide; type 2 diabetes, hyperglycemia, diabetes or insulin resistance, Syndrome X, atherosclerosis | MERCK & CO., INC. (US) | 2010-01-19 | — | — | US | disclosed |
| EP-1765335-B1 | PYRAZOLE AMIDE DERIVATIVES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20070203186-A1 | Pyrazole Amide Derivatives, Compositions Containing Such Compounds And Methods Of Use | MERCK & CO., INC. (US) | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203186-A1 | Pyrazole Amide Derivatives, Compositions Containing Such Compounds And Methods Of Use | AADAC, GOT2, GLS2 | GCGR 58/4885GIPR 70/4885PTGER4 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.