Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Naphthalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 known ✓ | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 known ✓ | P29475 | 2/20 | 0.39 |
| ▸ | NQO2 | P16083 | 5/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | F12 | P00748 | 1/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthalene SCHEMBL27610274 | 0.98 | NQO2 (0.46) | NQO2F2PRSS1PLGPLAU | |
| Naphthalene SCHEMBL28142060 | 0.95 | NQO2 (0.44) | NQO2F2PRSS1PLGPLAU | |
| Naphthalene SCHEMBL27929662 | 0.87 | CYP2A6 (0.50) | MAPTCYP3A4TSHRCYP2C19HSD17B10 | |
| Biphenyl SCHEMBL27879827 | 0.86 | NQO2 (0.53) | NQO2F2PRSS1MAPTBLM | |
| Naphthalene SCHEMBL3759523 | 0.84 | CYP2A6 (0.53) | MAPTCYP3A4TSHRCYP2C19HSD17B10 | |
| Naphthalene SCHEMBL28769152 | 0.84 | CYP2A6 (0.53) | MAPTCYP3A4TSHRCYP2C19HSD17B10 | |
| Naphthalene SCHEMBL27548576 | 0.84 | CYP2A6 (0.53) | MAPTCYP3A4TSHRCYP2C19HSD17B10 | |
| Naphthalene SCHEMBL263645 | 0.84 | CYP2A6 (0.53) | MAPTCYP3A4TSHRCYP2C19HSD17B10 | |
| Naphthalene SCHEMBL28104781 | 0.84 | CYP2A6 (0.53) | MAPTCYP3A4TSHRCYP2C19HSD17B10 | |
| Benzene SCHEMBL28073929 | 0.84 | FFAR3 (0.47) | NQO2F2MAPTBLMRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105652594-A | Self emission type photosensitive resin composition, color filter and image display device | 东友精细化工有限公司 | 2016-06-08 | — | — | CN | disclosed |