Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28075897 | 1.00 | LRRK2 (0.48) | LRRK2CTSLCTSBCTSSCTSK | |
| SCHEMBL28830376 | 0.86 | LRRK2 (0.37) | LRRK2 | |
| SCHEMBL28075910 | 0.83 | LRRK2 (0.48) | LRRK2CTSLCTSBCTSSCTSK | |
| SCHEMBL28075846 | 0.83 | LRRK2 (0.48) | LRRK2CTSLCTSBCTSSCTSK | |
| SCHEMBL14059811 | 0.74 | LRRK2 (0.65) | LRRK2AAK1 | |
| SCHEMBL14059810 | 0.74 | LRRK2 (0.65) | LRRK2AAK1 | |
| SCHEMBL14059203 | 0.74 | AAK1 (0.39) | LRRK2AAK1ROCK1PRKACAGSK3A | |
| SCHEMBL17135925 | 0.74 | LRRK2 (0.65) | LRRK2AAK1 | |
| SCHEMBL28076057 | 0.70 | LRRK2 (0.36) | LRRK2CSF1R | |
| SCHEMBL14059965 | 0.69 | LRRK2 (0.71) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | disclosed |