Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.30 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28075897 | 0.86 | LRRK2 (0.48) | LRRK2 | |
| SCHEMBL28830344 | 0.86 | LRRK2 (0.48) | LRRK2 | |
| SCHEMBL28076057 | 0.84 | LRRK2 (0.36) | LRRK2PDE7APDE7B | |
| SCHEMBL27975550 | 0.78 | LRRK2 (0.52) | LRRK2 | |
| SCHEMBL27975353 | 0.74 | LRRK2 (0.39) | LRRK2EGLN2 | |
| SCHEMBL27975173 | 0.73 | LRRK2 (0.38) | LRRK2 | |
| SCHEMBL27975446 | 0.73 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL28814172 | 0.71 | LRRK2 (0.53) | LRRK2 | |
| SCHEMBL28813534 | 0.71 | LRRK2 (0.70) | LRRK2 | |
| SCHEMBL28075910 | 0.70 | LRRK2 (0.48) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | disclosed |