Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.44 |
| ▸ | TTK | P33981 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 6/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.39 |
| ▸ | YES1 | P07947 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL615235 | 0.89 | ABL1 (0.51) | ABL1SRCPDGFRBYES1KDR | |
| SCHEMBL612493 | 0.89 | TTK (0.53) | ABL1TTKSRCJAK1JAK2 | |
| SCHEMBL614249 | 0.76 | JAK3 (0.46) | ABL1TTKSRCJAK1JAK2 | |
| SCHEMBL613380 | 0.74 | DRD2 (0.44) | ABL1SRCPDGFRBYES1KDR | |
| SCHEMBL41292 | 0.74 | LRRK2 (0.49) | ABL1TTKSRCJAK2JAK3 | |
| SCHEMBL612970 | 0.73 | SRC (0.62) | ABL1SRCJAK2JAK3PTK2 | |
| SCHEMBL614439 | 0.70 | TTK (0.42) | ABL1TTKSRCJAK2JAK3 | |
| SCHEMBL41896 | 0.70 | SRC (0.48) | ABL1SRCJAK2JAK3PTK2 | |
| SCHEMBL40869 | 0.70 | SRC (0.52) | ABL1SRCJAK2JAK3PTK2 | |
| SCHEMBL42448 | 0.70 | SRC (0.48) | ABL1TTKSRCJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396324-A1 | Ý1, 2, 4¨TRIAZOLO Ý1, 5 -A¨PYRIDINES AS KINASE INHIBITORS | Fovea Pharmaceuticals (FR) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092041-A1 | [1, 2, 4] TRIAZOLO [1, 5 -A] PYRIDINES AS KINASE INHIBITORS | FOVEA PHARMACEUTICALS SA (FR) | 2010-08-19 | — | — | WO | disclosed |