Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.49 |
| ▸ | KDM4A | O75164 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24352770 | 0.88 | KCNA5 (0.49) | KCNA5KDM4ACA12CA1CA7 | |
| SCHEMBL30159605 | 0.86 | KCNA5 (0.56) | KCNA5KDM4ACA12CA1CA7 | |
| SCHEMBL8018113 | 0.86 | KCNA5 (0.56) | KCNA5KDM4ACA12CA1CA7 | |
| SCHEMBL12280397 | 0.85 | KMT2A (0.47) | KCNA5KDM4ACA12CA1CA7 | |
| SCHEMBL6281581 | 0.81 | KDM4A (0.41) | KCNA5KDM4ACA12CA1CA7 | |
| SCHEMBL21048808 | 0.80 | TP53 (0.44) | KCNA5KDM4ACA12CA1CA7 | |
| SCHEMBL6874894 | 0.80 | KCNA5 (0.52) | KCNA5KDM4ACA12CA1CA7 | |
| SCHEMBL30454240 | 0.80 | KCNA5 (0.52) | KCNA5KDM4ACA12CA1CA7 | |
| SCHEMBL5792738 | 0.80 | KCNA5 (0.52) | KCNA5KDM4ACA12CA1CA7 | |
| SCHEMBL3124959 | 0.80 | ALDH1A1 (0.55) | KCNA5KDM4ALMNAPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114957219-B | Degradation agent for targeted degradation of Gli1 protein, preparation method and application thereof | 苏州大学 | 2023-12-15 | — | — | CN | claimed |
| CN-114957219-A | Degradation agent for targeted degradation of Gli1 protein and preparation method and application thereof | 苏州大学 | 2022-08-30 | — | — | CN | claimed |
| CN-114957219-B | Degradation agent for targeted degradation of Gli1 protein, preparation method and application thereof | 苏州大学 | 2023-12-15 | — | — | CN | disclosed |
| CN-114957219-A | Degradation agent for targeted degradation of Gli1 protein and preparation method and application thereof | 苏州大学 | 2022-08-30 | — | — | CN | disclosed |