Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenoperidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 9/20 | 0.56 |
| ▸ | OPRK1 known ✓ | P41145 | 6/20 | 0.56 |
| ▸ | KCNA3 | P22001 | 3/20 | 0.67 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Anileridine SCHEMBL26333 | 0.91 | KCNA3 (0.74) | KCNA3OPRM1OPRD1OPRK1SLC22A1 | |
| Anileridine SCHEMBL27722317 | 0.91 | KCNA3 (0.74) | KCNA3OPRM1OPRD1OPRK1SLC22A1 | |
| Anileridine SCHEMBL119086 | 0.90 | KCNA3 (0.72) | KCNA3OPRM1OPRD1OPRK1SLC22A1 | |
| Anileridine SCHEMBL7119028 | 0.90 | KCNA3 (0.72) | KCNA3OPRM1OPRD1OPRK1SLC22A1 | |
| Phenoperidine SCHEMBL80415 | 0.89 | KCNA3 (0.83) | KCNA3OPRM1OPRD1OPRK1SLC22A1 | |
| Phenoperidine SCHEMBL394330 | 0.88 | KCNA3 (0.81) | KCNA3OPRM1OPRD1OPRK1SLC22A1 | |
| Phenoperidine SCHEMBL1652634 | 0.88 | KCNA3 (0.80) | KCNA3OPRM1OPRD1OPRK1SLC22A1 | |
| Anileridine SCHEMBL1237724 | 0.87 | KCNA3 (0.69) | KCNA3OPRM1OPRD1OPRK1SLC22A1 | |
| Anileridine SCHEMBL8741179 | 0.84 | KCNA3 (0.66) | KCNA3OPRM1OPRD1OPRK1SLC22A1 | |
| Pheneridine SCHEMBL1922392 | 0.83 | KCNA3 (0.86) | KCNA3OPRM1OPRD1OPRK1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |