Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28092813 | 0.86 | EPHX2 (0.40) | EPHX2PIM1AVPR1ABRD4MEN1 | |
| SCHEMBL28092696 | 0.83 | EPHX2 (0.38) | EPHX2PIM1AVPR1ABRD4MEN1 | |
| SCHEMBL4793671 | 0.81 | BRD4 (0.41) | EPHX2PIM1AVPR1ABRD4MEN1 | |
| SCHEMBL30910112 | 0.80 | EPHX2 (0.55) | EPHX2AVPR1ABRD4MEN1KMT2A | |
| SCHEMBL6419724 | 0.80 | EPHX2 (0.55) | EPHX2AVPR1ABRD4MEN1KMT2A | |
| SCHEMBL30910110 | 0.80 | EPHX2 (0.55) | EPHX2AVPR1ABRD4MEN1KMT2A | |
| SCHEMBL9111246 | 0.79 | MEN1 (0.33) | EPHX2PIM1AVPR1ABRD4MEN1 | |
| SCHEMBL14497763 | 0.79 | MEN1 (0.49) | EPHX2PIM1AVPR1ABRD4MEN1 | |
| SCHEMBL30910128 | 0.77 | MEN1 (0.41) | EPHX2PIM1AVPR1ABRD4MEN1 | |
| SCHEMBL30910141 | 0.77 | AVPR1A (0.41) | EPHX2PIM1AVPR1ABRD4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106029076-A | Benzopiperazine compositions as BET bromodomain inhibitors | 福马疗法公司 | 2016-10-12 | — | — | CN | claimed |
| CN-106029076-B | Benzo piperazine composition as BET bromine domain inhibitor | 福马疗法公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-106029076-A | Benzopiperazine compositions as BET bromodomain inhibitors | 福马疗法公司 | 2016-10-12 | — | — | CN | disclosed |