Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28094612 | 0.86 | PDE10A (0.71) | PDE10AMEN1KMT2ARXFP1CA1 | |
| SCHEMBL13550372 | 0.82 | KDM4E (0.62) | PDE10AMEN1KMT2ARXFP1CA1 | |
| SCHEMBL6300664 | 0.81 | PDE10A (0.60) | PDE10AMEN1KMT2ARXFP1CA1 | |
| SCHEMBL28906438 | 0.80 | TUBB4A (0.67) | PDE10AMEN1KMT2ARXFP1CA1 | |
| SCHEMBL8020349 | 0.79 | PDE10A (0.64) | PDE10AMEN1KMT2ARXFP1CA1 | |
| SCHEMBL6922317 | 0.77 | PPARG (0.66) | PDE10AKDM4EALDH1A1TUBB4ATUBB | |
| SCHEMBL29432610 | 0.77 | DYRK1A (0.55) | PDE10AMEN1KMT2AHPGDKDM4E | |
| SCHEMBL19846959 | 0.77 | DYRK1A (0.55) | PDE10AMEN1KMT2AHPGDKDM4E | |
| SCHEMBL16814486 | 0.75 | KDM4E (0.57) | MEN1KMT2ARXFP1CA1CA2 | |
| SCHEMBL7234310 | 0.75 | PPARG (0.60) | PDE10AHPGDCYP1A2CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106008479-A | Substituted pyrimidine compound serving as phosphatidylinositol 3-kinase delta inhibitor and application thereof | 南京圣和药业股份有限公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-105936635-A | Compound as phosphatidylinositol 3-kinase delta inhibitor and application thereof | 南京圣和药业股份有限公司 | 2016-09-14 | — | — | CN | disclosed |