⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2883393 | 0.84 | TSHR (0.44) | — | |
| SCHEMBL28374143 | 0.80 | — | — | |
| SCHEMBL4743574 | 0.71 | — | — | |
| SCHEMBL2882738 | 0.71 | — | — | |
| SCHEMBL2886457 | 0.71 | — | — | |
| SCHEMBL2886356 | 0.71 | — | — | |
| SCHEMBL565804 | 0.71 | — | — | |
| SCHEMBL23306179 | 0.66 | — | — | |
| SCHEMBL20690140 | 0.64 | — | — | |
| SCHEMBL27995792 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082591-A1 | METHODS FOR PREPARING SULFONAMIDE COMPOUNDS | WYETH (US) | 2009-03-26 | — | — | US | claimed |
| US-7476762-B2 | Methods for preparing sulfonamide compounds | WYETH (US) | 2009-01-13 | — | — | US | claimed |
| US-20070249723-A1 | Methods for preparing sulfonamide compounds | WYETH (US) | 2007-10-25 | — | — | US | claimed |
| US-7858658-B2 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH LLC (US) | 2010-12-28 | — | — | US | disclosed |
| US-20090227667-A1 | FLUORO- AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF | WYETH (US) | 2009-09-10 | — | — | US | disclosed |
| US-20090221711-A1 | TRIFLUOROMETHYL-CONTAINING PHENYLSULFONAMIDE BETA AMYLOID INHIBITORS | WYETH (US) | 2009-09-03 | — | — | US | disclosed |
| US-7550629-B2 | 4-chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]benzenesulfonamide; 4-cyano-N-(3,3,3-trifluoro-1-hydroxymethyl-2-trifluoromethyl-propyl)-benzenesulfonamide; Alzheimer's Disease, amyloid angiopathy, systemic amyloidosis, mild cognitive impairment and Down's syndrome | WYETH (US) | 2009-06-23 | — | — | US | disclosed |
| US-7547725-B2 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH (US) | 2009-06-16 | — | — | US | disclosed |
| US-20090082591-A1 | METHODS FOR PREPARING SULFONAMIDE COMPOUNDS | WYETH (US) | 2009-03-26 | — | — | US | disclosed |
| US-20090082591-A1 | METHODS FOR PREPARING SULFONAMIDE COMPOUNDS | WYETH (US) | 2009-03-26 | — | — | US | disclosed |
| US-20090082591-A1 | METHODS FOR PREPARING SULFONAMIDE COMPOUNDS | WYETH (US) | 2009-03-26 | — | — | US | disclosed |
| US-7300951-B2 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH (US) | 2007-11-27 | — | — | US | disclosed |
| US-20070254929-A1 | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH (US) | 2007-11-01 | — | — | US | disclosed |
| US-20070249723-A1 | Methods for preparing sulfonamide compounds | WYETH (US) | 2007-10-25 | — | — | US | disclosed |
| US-20070249723-A1 | Methods for preparing sulfonamide compounds | WYETH (US) | 2007-10-25 | — | — | US | disclosed |
| US-20070249722-A1 | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors | WYETH (US) | 2007-10-25 | — | — | US | disclosed |
| US-20070249723-A1 | Methods for preparing sulfonamide compounds | WYETH (US) | 2007-10-25 | — | — | US | disclosed |
| EP-1608638-A1 | FLUORO-AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF | Wyeth (US) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004092155-A1 | FLUORO-AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF | WYETH (US) | 2004-10-28 | — | — | WO | disclosed |
| US-20040198778-A1 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH | 2004-10-07 | — | — | US | disclosed |