Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2883405 | 0.84 | — | — | |
| SCHEMBL13873167 | 0.77 | TSHR (0.46) | TSHRSMN1; SMN2 | |
| SCHEMBL20820008 | 0.74 | TSHR (0.50) | TSHRSMN1; SMN2 | |
| SCHEMBL29715 | 0.74 | — | — | |
| SCHEMBL10786843 | 0.72 | — | — | |
| SCHEMBL10923089 | 0.72 | — | — | |
| SCHEMBL8405269 | 0.72 | — | — | |
| SCHEMBL28374143 | 0.71 | — | — | |
| SCHEMBL17715108 | 0.69 | TSHR (0.70) | TSHRSMN1; SMN2 | |
| SCHEMBL1950732 | 0.69 | TSHR (0.55) | TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1780829-B | Fluorine-containing and trifluoroalkyl heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH CORP | 2010-12-29 | — | — | CN | disclosed |
| US-7858658-B2 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH LLC (US) | 2010-12-28 | — | — | US | disclosed |
| US-20090227667-A1 | FLUORO- AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF | WYETH (US) | 2009-09-10 | — | — | US | disclosed |
| US-7547725-B2 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH (US) | 2009-06-16 | — | — | US | disclosed |
| CN-101274926-A | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH CORP (US) | 2008-10-01 | — | — | CN | disclosed |
| US-7300951-B2 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH (US) | 2007-11-27 | — | — | US | disclosed |
| US-20070254929-A1 | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH (US) | 2007-11-01 | — | — | US | disclosed |
| CN-1780829-A | Fluorine-containing and trifluoroalkyl heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH CORP (US) | 2006-05-31 | — | — | CN | disclosed |
| EP-1608638-A1 | FLUORO-AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF | Wyeth (US) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004092155-A1 | FLUORO-AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF | WYETH (US) | 2004-10-28 | — | — | WO | disclosed |
| US-20040198778-A1 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254929-A1 | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | SCN8A, CHD8, CHRNA7 | TSHR 202/4885SMN1; SMN2 1061/4885 |
| US-20090227667-A1 | FLUORO- AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF | SCN8A, CHD8, CDR2 | TSHR 212/4885SMN1; SMN2 1154/4885 |
| US-20040198778-A1 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | BACE1, APP, PSEN1 | TSHR 835/4885SMN1; SMN2 469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.