Sugi Predict

Sugi Predict / Compounds / SCHEMBL2883556

SCHEMBL2883556

SCHEMBL2883556

CCOC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)nc1CNC(C(=O)OCC)C(=O)OC(C)(C)C

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.58
▸ MEN1 O00255 2/20 0.58
▸ KMT2A Q03164 2/20 0.58
▸ KDM4E B2RXH2 1/20 0.58
▸ HSP90AA1 P07900 1/20 0.58
▸ CRHBP P24387 1/20 0.58
▸ CRHR2 Q13324 1/20 0.58
▸ NPC1 O15118 1/20 0.45
▸ ALDH1A1 P00352 1/20 0.45
▸ GAA P10253 1/20 0.45
▸ DHODH Q02127 1/20 0.45
▸ TRPM8 Q7Z2W7 4/20 0.44
▸ CDC7 O00311 7/20 0.43
▸ DBF4 Q9UBU7 7/20 0.43
▸ PPARA Q07869 3/20 0.42
▸ PTPN11 Q06124 1/20 0.42
▸ PPARG P37231 1/20 0.42
▸ PPARD Q03181 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2883593 0.89 TRPM8 (0.55) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL4804421 0.80 MAPT (0.76) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL4484447 0.80 MAPT (0.76) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL4809764 0.79 MAPT (0.74) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL4467429 0.79 MAPT (0.74) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL14394668 0.78 MAPT (0.73) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL2885122 0.78 MAPT (0.73) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL4468293 0.78 MAPT (0.73) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL4807448 0.78 MAPT (0.69) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL4809770 0.76 MAPT (0.70) MAPTMEN1KMT2AKDM4EHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2373318-B1 IMIDAZOPYRAZINE SYK INHIBITORS GILEAD CONNECTICUT INC (US) 2019-06-05 — — EP claimed
US-20170121350-A1 IMIDAZOPYRAZINE SYK INHIBITORS Kronos Bio, Inc. 2017-05-04 — — US claimed
US-8962835-B2 Imidazopyrazine Syk inhibitors GILEAD CONNECTICUT, INC. (US) 2015-02-24 — — US claimed
US-20130310363-A1 IMIDAZOPYRIZINE SYK INHIBITORS GILEAD CONNECTICUT, INC. (US) 2013-11-21 — — US claimed
US-20130231330-A1 IMIDAZOPYRIZINE SYK INHIBITORS GILEAD CONNECTICUT, INC. (US) 2013-09-05 — — US claimed
US-8440667-B2 Imidazopyrazine Syk inhibitors GILEAD CONNECTICUT, INC. (US) 2013-05-14 — — US claimed
US-20100152159-A1 IMIDAZOPYRAZINE SYK INHIBITORS Kronos Bio, Inc. 2010-06-17 — — US claimed
EP-3124489-B1 THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS FIBROGEN INC (US) 2020-07-15 — — EP disclosed
EP-3552607-A2 IMIDAZOPYRAZINE SYK INHIBITORS Gilead Connecticut, Inc. (US) 2019-10-16 — — EP disclosed
EP-2373318-B1 IMIDAZOPYRAZINE SYK INHIBITORS GILEAD CONNECTICUT INC (US) 2019-06-05 — — EP disclosed
EP-2373318-B1 IMIDAZOPYRAZINE SYK INHIBITORS GILEAD CONNECTICUT INC (US) 2019-06-05 — — EP disclosed
US-10093684-B2 Substituted imidazo[1,2-a]pyrazines as Syk inhibitors GILEAD CONNECTICUT, INC. (US) 2018-10-09 — — US disclosed
US-20170121350-A1 IMIDAZOPYRAZINE SYK INHIBITORS Kronos Bio, Inc. 2017-05-04 — — US disclosed
US-20100152159-A1 IMIDAZOPYRAZINE SYK INHIBITORS Kronos Bio, Inc. 2010-06-17 — — US disclosed
WO-2010068258-A1 IMIDAZOPYRAZINE SYK INHIBITORS CGI PHARMACEUTICALS, INC. (US) 2010-06-17 — — WO disclosed
US-20100152159-A1 IMIDAZOPYRAZINE SYK INHIBITORS Kronos Bio, Inc. 2010-06-17 — — US disclosed
US-7696223-B2 [(2-bromo-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carbonyl)-amino]-acetic acid; modulates the stability and/or activity of hypoxia inducible factor (HIF) FIBROGEN, INC. (US) 2010-04-13 — — US disclosed
EP-2016078-A2 PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS FIBROGEN, INC. (US) 2009-01-21 — — EP disclosed
US-20080004309-A1 PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF FIBROGEN, INC. 2008-01-03 — — US disclosed
WO-2007115315-A2 PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS FIBROGEN, INC. (US) 2007-10-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10093684-B2 Substituted imidazo[1,2-a]pyrazines as Syk inhibitors SYK, BTK, ZAP70 MAPT 3905/4885MEN1 3991/4885KMT2A 693/4885
US-20130310363-A1 IMIDAZOPYRIZINE SYK INHIBITORS SYK, BTK, ZAP70 MAPT 3873/4885MEN1 3626/4885KMT2A 1066/4885
US-20130231330-A1 IMIDAZOPYRIZINE SYK INHIBITORS SYK, ZAP70, BTK MAPT 3847/4885MEN1 4300/4885KMT2A 1019/4885
US-20170121350-A1 IMIDAZOPYRAZINE SYK INHIBITORS SYK, BTK, ZAP70 MAPT 3775/4885MEN1 4290/4885KMT2A 1035/4885
US-20100152159-A1 IMIDAZOPYRAZINE SYK INHIBITORS SYK, BTK, ZAP70 MAPT 3775/4885MEN1 4290/4885KMT2A 1035/4885
US-20080004309-A1 PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF HIF1AN, HIF1A, EGLN2 MAPT 2965/4885MEN1 4211/4885KMT2A 1354/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.