Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017853 | 0.78 | SMN1; SMN2 (0.53) | MAPTKMT2ATSHREGFRSRC | |
| SCHEMBL3884447 | 0.74 | EGFR (0.46) | MAPTKMT2ATSHRALOX15EGFR | |
| SCHEMBL6595214 | 0.72 | TSHR (0.64) | MAPTKMT2ATSHREGFRSRC | |
| SCHEMBL35212204 | 0.72 | TSHR (0.64) | MAPTKMT2ATSHREGFRSRC | |
| SCHEMBL2662560 | 0.72 | EGFR (0.53) | KMT2ATSHREGFRSRCMEN1 | |
| Hydrochloric Acid SCHEMBL28262758 | 0.71 | TSHR (0.62) | MAPTKMT2ATSHREGFRSRC | |
| SCHEMBL28265810 | 0.71 | EGFR (0.51) | KMT2ATSHREGFRSRCMEN1 | |
| SCHEMBL3879261 | 0.69 | MAPT (0.50) | MAPTKMT2ATSHREGFRSRC | |
| SCHEMBL14236771 | 0.69 | ALDH1A1 (0.50) | MAPTKMT2ATSHRF2ALOX15 | |
| SCHEMBL11310708 | 0.68 | EGFR (0.49) | MAPTKMT2ATSHRALOX15EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106456602-A | Substituted indole MCL-1 inhibitors | 范德比尔特大学 | 2017-02-22 | — | — | CN | disclosed |