SCHEMBL28835947

SCHEMBL28835947

CCCCCOC1(C(=O)OC)C(F)=C(F)C(c2ccccc2)=C(F)C1F

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 2/20 0.36
KDM4E B2RXH2 4/20 0.35
CHRM3 P20309 8/20 0.34
CNR2 P34972 1/20 0.34
ALDH1A1 P00352 3/20 0.33
MEN1 O00255 2/20 0.33
MAPT P10636 2/20 0.33
CYP2C9 P11712 2/20 0.33
CYP2C19 P33261 2/20 0.33
KMT2A Q03164 2/20 0.33
NR5A1 Q13285 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
HSD17B10 Q99714 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
SOAT1 P35610 2/20 0.33
LMNA P02545 1/20 0.33
RECQL P46063 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28835923 0.99 CHRM3 (0.35) PTPN1KDM4ECHRM3ALDH1A1MEN1
SCHEMBL28836033 0.84 MEN1 (0.35) KDM4ECHRM3ALDH1A1MEN1MAPT
SCHEMBL28835979 0.79 CYP1A2 (0.32) KDM4EALDH1A1MEN1MAPTCYP2C9
SCHEMBL28835982 0.74 MEN1 (0.33) KDM4EALDH1A1MEN1MAPTCYP2C9
SCHEMBL28835983 0.71 MEN1 (0.35) KDM4ECHRM3ALDH1A1MEN1MAPT
SCHEMBL28836036 0.64 HTT (0.34) CHRM3ALDH1A1MEN1CYP2C9CYP2C19
SCHEMBL7788909 0.63 NR5A1 (0.36) PTPN1CHRM3CNR2ALDH1A1MEN1
SCHEMBL29779547 0.62
SCHEMBL9494241 0.61 NR5A1 (0.34) PTPN1ALDH1A1MEN1CYP2C9CYP2C19
SCHEMBL28581527 0.61 PDE4B (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115010600-B Method for synthesizing polyfluoroaryl carboxylic acid compound based on aryl fluorocarbon bond carboxylation reaction 四川大学 2023-11-17 CN disclosed
CN-115010600-A Method for synthesizing polyfluoroaryl carboxylic acid compounds based on aryl fluorocarbon bond carboxylation reaction 四川大学 2022-09-06 CN disclosed