SCHEMBL28835982

SCHEMBL28835982

COC(=O)C1(SC)C(F)=C(F)C(c2ccccc2)=C(F)C1F

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.33
KMT2A Q03164 5/20 0.33
CYP1A2 P05177 4/20 0.33
CYP3A4 P08684 4/20 0.33
CYP2C9 P11712 4/20 0.33
CYP2C19 P33261 4/20 0.33
ALDH1A1 P00352 4/20 0.33
HTT P42858 2/20 0.33
PDE4B Q07343 1/20 0.33
FGFR1 P11362 1/20 0.32
SRC P12931 1/20 0.32
FGFR2 P21802 1/20 0.32
FGFR4 P22455 1/20 0.32
FGFR3 P22607 1/20 0.32
HSD17B10 Q99714 3/20 0.31
HPGD P15428 2/20 0.31
CYP2D6 P10635 1/20 0.31
TSHR P16473 1/20 0.31
CASP1 P29466 1/20 0.31
CASP7 P55210 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28836033 0.81 MEN1 (0.35) MEN1KMT2ACYP1A2CYP3A4CYP2C9
SCHEMBL28835983 0.78 MEN1 (0.35) MEN1KMT2ACYP1A2CYP3A4CYP2C9
SCHEMBL28835979 0.76 CYP1A2 (0.32) MEN1KMT2ACYP1A2CYP3A4CYP2C9
SCHEMBL28835947 0.74 PTPN1 (0.36) MEN1KMT2ACYP1A2CYP3A4CYP2C9
SCHEMBL28835923 0.73 CHRM3 (0.35) MEN1KMT2ACYP2C9CYP2C19ALDH1A1
SCHEMBL28432428 0.70 PDE4B (0.36) ALDH1A1HTTPDE4BMAPTMITF
SCHEMBL28581527 0.66 PDE4B (0.33) PDE4B
SCHEMBL28963824 0.65
SCHEMBL29779547 0.64
SCHEMBL29074280 0.62 ALDH1A1 (0.33) CYP3A4CYP2C9CYP2C19ALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115010600-B Method for synthesizing polyfluoroaryl carboxylic acid compound based on aryl fluorocarbon bond carboxylation reaction 四川大学 2023-11-17 CN disclosed
CN-115010600-A Method for synthesizing polyfluoroaryl carboxylic acid compounds based on aryl fluorocarbon bond carboxylation reaction 四川大学 2022-09-06 CN disclosed