Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | CCR3 | P51677 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11256637 | 0.98 | POLB (0.66) | OPRL1POLBCCR3OPRM1OPRD1 | |
| SCHEMBL23780161 | 0.90 | OPRL1 (0.61) | OPRL1POLBCCR3OPRM1OPRD1 | |
| SCHEMBL30136893 | 0.86 | OPRL1 (0.57) | OPRL1POLBCCR3CYP3A4HSD17B10 | |
| SCHEMBL16836087 | 0.86 | OPRL1 (0.57) | OPRL1POLBCCR3OPRM1OPRD1 | |
| SCHEMBL16836251 | 0.86 | OPRL1 (0.57) | OPRL1POLBCCR3CYP3A4HSD17B10 | |
| SCHEMBL1266987 | 0.86 | OPRL1 (0.58) | OPRL1POLBCCR3CYP3A4HSD17B10 | |
| SCHEMBL6911078 | 0.86 | OPRL1 (0.71) | OPRL1POLBCCR3CYP3A4HSD17B10 | |
| SCHEMBL10916463 | 0.85 | OPRL1 (0.70) | OPRL1POLBCCR3CYP3A4HSD17B10 | |
| SCHEMBL6649554 | 0.84 | OPRL1 (0.56) | OPRL1POLBCCR3CYP3A4HSD17B10 | |
| SCHEMBL6967833 | 0.84 | OPRL1 (0.56) | OPRL1POLBCCR3CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828385-B2 | Spiro-oxazolones | HOFFMANN-LA ROCHE INC. (US) | 2017-11-28 | — | — | US | disclosed |
| US-20170008901-A1 | SPIRO-OXAZOLONES | HOFFMANN-LA ROCHE INC. (US) | 2017-01-12 | — | — | US | disclosed |
| US-20160355522-A1 | SPIRO-OXAZOLONES | HOFFMANN-LA ROCHE INC. (US) | 2016-12-08 | — | — | US | disclosed |
| US-7855294-B2 | Cycloalkanopyridine derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-12-21 | — | — | US | disclosed |
| US-20070191419-A1 | Cycloalkanopyridine derivative | MSD K.K. (JP) | 2007-08-16 | — | — | US | disclosed |
| EP-1726590-A1 | CYCLOALKANOPYRIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160355522-A1 | SPIRO-OXAZOLONES | AVPR1A, AVPR1B, AVPR2 | OPRL1 7/4885POLB 2449/4885CCR3 1985/4885 |
| US-20170008901-A1 | SPIRO-OXAZOLONES | AVPR1A, AVPR1B, AVPR2 | OPRL1 7/4885POLB 2449/4885CCR3 1985/4885 |
| US-20070191419-A1 | Cycloalkanopyridine derivative | OPRL1, OPRK1, AVPR2 | OPRL1 1/4885POLB 3327/4885CCR3 2157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.