Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 12/20 | 0.69 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.69 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.69 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.69 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.69 |
| ▸ | ALB | P02768 | 1/20 | 0.69 |
| ▸ | ESR1 | P03372 | 1/20 | 0.69 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.69 |
| ▸ | RARB | P10826 | 1/20 | 0.69 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.69 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.69 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27633561 | 0.85 | PTGS2 (0.50) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL59197 | 0.84 | PTGS2 (0.74) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL30978352 | 0.84 | PTGS2 (0.65) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL1512673 | 0.83 | PTGS2 (0.69) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL29390746 | 0.83 | PTGS2 (0.69) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL6369574 | 0.82 | AKR1C3 (0.77) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL680055 | 0.82 | AKR1C3 (0.77) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL1345506 | 0.82 | PTGS2 (0.67) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL1061942 | 0.82 | PTGS2 (0.67) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| Ibuprofen SCHEMBL239446 | 0.82 | PTGS1 (1.00) | PTGS2PTGS1AKR1C3LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4368353-A | — | — | None | — | — | JP | disclosed |
| CN-108586233-B | Method for synthesizing 2- (4' -bromomethylphenyl) propionate | 湖北迅达药业股份有限公司 | 2021-05-18 | — | — | CN | disclosed |
| CN-108586233-A | The method for synthesizing 2- (4 ' -2-bromomethylphenyl) propionic ester | 湖北迅达药业股份有限公司 | 2018-09-28 | — | — | CN | disclosed |
| CN-102424681-B | Acyl-tetrahydro-beta-carboline compound as well as derivatives, application and preparation method thereof | EAST CHINA NORMAL UNIVERSITY (CN) | 2014-10-15 | — | — | CN | disclosed |
| CN-102424681-A | Acyl-tetrahydro-beta-carboline compound as well as derivatives, application and preparation method thereof | UNIV EAST CHINA NORMAL | 2012-04-25 | — | — | CN | disclosed |
| US-20110212989-A1 | THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING ISOFLAVONES | NOVOGEN RESEARCH PTY LTD (AU) | 2011-09-01 | — | — | US | disclosed |
| US-20110212989-A1 | THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING ISOFLAVONES | NOVOGEN RESEARCH PTY LTD (AU) | 2011-09-01 | — | — | US | disclosed |
| US-7915308-B2 | Therapeutic methods and compositions involving isoflavones | NOVOGEN RESEARCH PTY LTD (AU) | 2011-03-29 | — | — | US | disclosed |
| US-7915308-B2 | Therapeutic methods and compositions involving isoflavones | NOVOGEN RESEARCH PTY LTD (AU) | 2011-03-29 | — | — | US | disclosed |
| US-20100216758-A1 | Pyridone Compounds | MSD K.K. (JP) | 2010-08-26 | — | — | US | disclosed |
| US-20080287528-A1 | THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING ISOFLAVONES | NOVOGEN RESEARCH PTY LIMITED (AU) | 2008-11-20 | — | — | US | disclosed |
| US-20080287528-A1 | THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING ISOFLAVONES | NOVOGEN RESEARCH PTY LIMITED (AU) | 2008-11-20 | — | — | US | disclosed |
| US-7419998-B2 | Therapeutic methods and compositions involving isoflavones | NOVOGEN RESEARCH PTY LTD (AU) | 2008-09-02 | — | — | US | disclosed |
| EP-1927352-A2 | Therapeutic methods and compositions involving isoflavones | Novogen Research Pty. Ltd. (AU) | 2008-06-04 | — | — | EP | disclosed |
| US-7202273-B2 | Therapeutic methods and compositions involving isoflavones | NOVOGEN RESEARCH PTY LTD (AU) | 2007-04-10 | — | — | US | disclosed |
| JP-H04368353-A | PRODUCTION OF 2-(P-FORMYLPHENYL)PROPIONIC ACID | SANKYO CO LTD | 1992-12-21 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216758-A1 | Pyridone Compounds | NPY1R, MC5R, MC1R | PTGS2 1964/4885PTGS1 1485/4885AKR1C3 188/4885 |
| US-20110212989-A1 | THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING ISOFLAVONES | C1R, C1S, ESRRA | PTGS2 2417/4885PTGS1 1908/4885AKR1C3 21/4885 |
| US-20080287528-A1 | THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING ISOFLAVONES | C1R, ESRRA, ESRRB | PTGS2 2424/4885PTGS1 1912/4885AKR1C3 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.