Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
| ▸ | YAP1 | P46937 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28838656 | 1.00 | USP30 (0.48) | USP30L3MBTL1MAPTMAPK1NPSR1 | |
| SCHEMBL23343010 | 1.00 | USP30 (0.48) | USP30L3MBTL1MAPTMAPK1NPSR1 | |
| SCHEMBL23342997 | 1.00 | USP30 (0.48) | USP30L3MBTL1MAPTMAPK1NPSR1 | |
| SCHEMBL23342998 | 1.00 | USP30 (0.48) | USP30L3MBTL1MAPTMAPK1NPSR1 | |
| SCHEMBL23298232 | 0.88 | CYP2C19 (0.43) | CYP3A4CYP2C9CYP2C19FKBP1A | |
| SCHEMBL23298255 | 0.88 | CYP2C19 (0.43) | CYP3A4CYP2C9CYP2C19FKBP1A | |
| SCHEMBL23298237 | 0.88 | CYP2C19 (0.43) | CYP3A4CYP2C9CYP2C19FKBP1A | |
| SCHEMBL23298235 | 0.88 | CYP2C19 (0.43) | CYP3A4CYP2C9CYP2C19FKBP1A | |
| SCHEMBL23298258 | 0.88 | CYP2C19 (0.43) | CYP3A4CYP2C9CYP2C19FKBP1A | |
| SCHEMBL29543073 | 0.86 | CCR5 (0.43) | L3MBTL1MAPK1ALDH1A1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117715658-A | Method for inhibiting RAS | 锐新医药公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-116209438-A | Treatment of malignant diseases with SHP2 mutations using SOS1 inhibitors | 锐新医药公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-115916194-A | Methods for delaying, preventing and treating acquired resistance to RAS inhibitors | 锐新医药公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115873020-A | RAS inhibitors | 锐新医药公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-114901366-A | RAS inhibitors | 锐新医药公司 | 2022-08-12 | — | — | CN | disclosed |