Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 13/20 | 0.42 |
| ▸ | TYK2 | P29597 | 13/20 | 0.42 |
| ▸ | JAK2 | O60674 | 12/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | PTPRF | P10586 | 1/20 | 0.35 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29739841 | 1.00 | JAK1 (0.42) | JAK1TYK2JAK2KCNH2PDE4D | |
| SCHEMBL30490285 | 0.92 | TYK2 (0.41) | JAK1TYK2JAK2KCNH2PDE4D | |
| SCHEMBL28839791 | 0.90 | JAK1 (0.40) | JAK1TYK2JAK2KCNH2PDE4D | |
| SCHEMBL29739920 | 0.90 | JAK1 (0.40) | JAK1TYK2JAK2KCNH2PDE4D | |
| SCHEMBL29739986 | 0.90 | JAK1 (0.40) | JAK1TYK2JAK2KCNH2PDE4D | |
| SCHEMBL28839029 | 0.90 | JAK1 (0.40) | JAK1TYK2JAK2KCNH2PDE4D | |
| SCHEMBL30490264 | 0.88 | TYK2 (0.41) | JAK1TYK2JAK2KCNH2PDE4D | |
| SCHEMBL26117687 | 0.86 | TYK2 (0.44) | JAK1TYK2JAK2KCNH2PDE4D | |
| SCHEMBL29684948 | 0.86 | TYK2 (0.44) | JAK1TYK2JAK2KCNH2PDE4D | |
| SCHEMBL26534722 | 0.85 | TYK2 (0.44) | JAK1TYK2JAK2KCNH2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901656-B | Hydroximic acid ester compound, preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-114901656-A | Hydroximic acid ester compound, preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2022-08-12 | — | — | CN | disclosed |