Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 8/20 | 0.97 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9387969 | 0.98 | IDO1 (1.00) | IDO1LMNAMTNR1ATP53HSD17B10 | |
| SCHEMBL28839376 | 0.92 | IDO1 (0.88) | IDO1LMNAMTNR1ATP53HSD17B10 | |
| SCHEMBL880307 | 0.81 | IDO1 (0.70) | IDO1LMNAMTNR1ATP53HSD17B10 | |
| SCHEMBL17258102 | 0.81 | IDO1 (1.00) | IDO1LMNA | |
| SCHEMBL17258070 | 0.81 | IDO1 (0.71) | IDO1LMNATP53 | |
| SCHEMBL17258148 | 0.81 | IDO1 (1.00) | IDO1LMNATP53HSD17B10MAPT | |
| SCHEMBL17258053 | 0.81 | IDO1 (0.71) | IDO1LMNATP53HSD17B10MAPT | |
| SCHEMBL880259 | 0.75 | IDO1 (0.60) | IDO1LMNAMTNR1ATP53HSD17B10 | |
| SCHEMBL5323542 | 0.75 | IDO1 (0.61) | IDO1LMNA | |
| SCHEMBL6918058 | 0.75 | IDO1 (0.61) | IDO1LMNADDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073643-A | Preparation method of poly 4-methyl-1-pentene material, catalyst system and application thereof | 宁夏清研高分子新材料有限公司 | 2022-09-20 | — | — | CN | disclosed |