Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13522417 | 0.85 | PKM (0.70) | IDO1ALOX15PKMMEN1KMT2A | |
| SCHEMBL14450498 | 0.81 | IDO1 (0.56) | IDO1ALOX15PKMMEN1KMT2A | |
| SCHEMBL9387969 | 0.76 | IDO1 (1.00) | IDO1TP53HSD17B10MTNR1ALMNA | |
| Bromide SCHEMBL28839335 | 0.75 | IDO1 (0.97) | IDO1TP53HSD17B10MTNR1ALMNA | |
| SCHEMBL880307 | 0.72 | IDO1 (0.70) | IDO1KMT2ATP53HSD17B10MTNR1A | |
| SCHEMBL28839376 | 0.71 | IDO1 (0.88) | IDO1ALOX15PKMTP53HSD17B10 | |
| SCHEMBL880405 | 0.70 | HTT (0.54) | PKMKMT2ATSHRGPBAR1TP53 | |
| SCHEMBL3004441 | 0.70 | IDO1 (0.58) | IDO1MEN1KMT2AATMTP53 | |
| SCHEMBL880422 | 0.69 | MAPT (0.47) | ALOX15TSHRGPBAR1TP53HSD17B10 | |
| SCHEMBL7814723 | 0.69 | MAPT (0.53) | IDO1MEN1KMT2AATMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-1802303-B1 | COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY | WHITEHEAD BIOMEDICAL INST (US) | 2011-11-02 | — | — | EP | disclosed |