Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 6/20 | 0.52 |
| ▸ | AURKA | O14965 | 5/20 | 0.52 |
| ▸ | MET | P08581 | 5/20 | 0.52 |
| ▸ | TEK | Q02763 | 5/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30229311 | 1.00 | PDGFRB (0.64) | PDGFRBPDGFRAKDRAURKAMET | |
| SCHEMBL30152477 | 1.00 | PDGFRB (0.64) | PDGFRBPDGFRAKDRAURKAMET | |
| SCHEMBL29535684 | 0.94 | PDGFRB (0.64) | PDGFRBPDGFRAKDRAURKAMET | |
| SCHEMBL23924017 | 0.94 | PDGFRB (0.64) | PDGFRBPDGFRAKDRAURKAMET | |
| Hydrochloric Acid SCHEMBL27894607 | 0.93 | PDGFRB (0.62) | PDGFRBPDGFRAKDRAURKAMET | |
| SCHEMBL29372253 | 0.88 | PDGFRB (0.56) | PDGFRBPDGFRAKDRAURKAMET | |
| SCHEMBL30616268 | 0.87 | PDGFRB (0.66) | PDGFRBPDGFRAAURKAKDM4EALDH1A1 | |
| SCHEMBL30616306 | 0.85 | PDGFRB (0.64) | PDGFRBPDGFRAAURKAKDM4EALDH1A1 | |
| SCHEMBL30196845 | 0.85 | IRAK4 (0.68) | PDGFRBPDGFRAMKNK1MKNK2IRAK4 | |
| SCHEMBL23640270 | 0.81 | PDGFRB (0.66) | PDGFRBPDGFRAKDRAURKAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106458912-B | Bicyclic fused heteroaryl or aryl compounds and their use as IRAK4 mimetics | 辉瑞公司 | 2020-10-27 | — | — | CN | disclosed |
| CN-106458912-A | Bicyclic fused heteroaryl or aryl compounds and their use as IRAK4 mimetics | 辉瑞公司 | 2017-02-22 | — | — | CN | disclosed |