Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dopamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | RECQL | P46063 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | DRD1 | P21728 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 2/20 | 0.57 |
| ▸ | DRD5 | P21918 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | DRD3 | P35462 | 2/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dopamine SCHEMBL28310234 | 0.90 | KDM4E (0.58) | KDM4ERECQLTDP1ALOX15PTGS1 | |
| Dopamine SCHEMBL524895 | 0.90 | KDM4E (0.58) | KDM4ERECQLTDP1ALOX15PTGS1 | |
| Levodopa SCHEMBL23069524 | 0.86 | SLC7A5 (0.77) | KDM4ERECQLTDP1ALOX15PTGS1 | |
| Levodopa SCHEMBL28250803 | 0.86 | SLC7A5 (0.77) | KDM4ERECQLTDP1ALOX15PTGS1 | |
| Levodopa SCHEMBL5494247 | 0.83 | SLC7A5 (0.82) | KDM4ERECQLTDP1ALOX15PTGS1 | |
| Levodopa SCHEMBL1491628 | 0.83 | SLC7A5 (0.82) | KDM4ERECQLTDP1ALOX15PTGS1 | |
| Levodopa SCHEMBL1491625 | 0.83 | SLC7A5 (0.82) | KDM4ERECQLTDP1ALOX15PTGS1 | |
| Levodopa SCHEMBL5494243 | 0.83 | SLC7A5 (0.82) | KDM4ERECQLTDP1ALOX15PTGS1 | |
| Dopamine SCHEMBL16915281 | 0.83 | KDM4E (0.55) | KDM4ERECQLTDP1ALOX15PTGS1 | |
| Dopamine SCHEMBL16915282 | 0.83 | KDM4E (0.55) | KDM4ERECQLTDP1ALOX15PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115043901-B | Dopaminization modified glutamine polypeptide, antibody thereof and application thereof | 济宁医学院附属医院 | 2023-08-29 | — | — | CN | disclosed |
| CN-115043901-A | Dopamine modified glutamine polypeptide and antibody and application thereof | 济宁医学院附属医院 | 2022-09-13 | — | — | CN | disclosed |