Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20177039 | 0.78 | LMNA (0.53) | LMNASMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL23769697 | 0.77 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL23754103 | 0.75 | TSHR (0.40) | LMNASMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL15273732 | 0.72 | SMN1; SMN2 (0.48) | ELANELMNASMN1; SMN2POLBNPC1 | |
| SCHEMBL25632856 | 0.72 | SMN1; SMN2 (0.45) | ELANELMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL4682118 | 0.72 | MAPT (0.47) | ELANELMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL29047841 | 0.70 | ELANE (0.46) | ELANELMNASMN1; SMN2POLBNPC1 | |
| SCHEMBL25390753 | 0.68 | TSHR (0.35) | ELANELMNASMN1; SMN2POLBNPC1 | |
| SCHEMBL20140164 | 0.68 | TDP1 (0.39) | LMNASMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL23041539 | 0.67 | POLB (0.46) | LMNAPOLBALDH1A1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116120287-B | Heteroaromatic carboxamide derivatives as inhibitors of plasma kallikrein | 勃林格殷格翰国际有限公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-116120287-A | Heteroaromatic carboxamide derivatives as inhibitors of plasma kallikrein | 勃林格殷格翰国际有限公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-115052873-A | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | 勃林格殷格翰国际有限公司 | 2022-09-13 | — | — | CN | disclosed |