Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL16778301 | 0.98 | HRH3 (1.00) | — | |
| Histamine SCHEMBL17377087 | 0.98 | — | — | |
| Histamine SCHEMBL15532340 | 0.96 | HRH3 (0.91) | — | |
| Histamine SCHEMBL123245 | 0.88 | HRH3 (0.78) | — | |
| Histamine SCHEMBL27939119 | 0.87 | HRH3 (0.75) | — | |
| Homohistamine SCHEMBL2092691 | 0.86 | — | — | |
| SCHEMBL8963903 | 0.85 | HRH3 (0.73) | — | |
| Imbutamine SCHEMBL28015739 | 0.85 | HRH3 (1.00) | — | |
| Homohistamine SCHEMBL9799515 | 0.85 | HRH3 (0.96) | — | |
| Histamine SCHEMBL3960364 | 0.84 | HRH3 (0.70) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 564 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118185783-A | Arthrobacter urealyticum strain 05-507, biocontrol agent and application thereof | 云南省烟草农业科学研究院 | 2024-06-14 | — | — | CN | claimed |
| CN-117736910-A | Achromobacter delbrueckii 79A6 for preventing and treating tobacco bacterial wilt and application thereof | 云南省烟草农业科学研究院 | 2024-03-22 | — | — | CN | claimed |
| CN-117603864-A | Aeromonas hydrophila ZTYL3 for preventing and treating tobacco bacterial wilt and application thereof | 云南省烟草农业科学研究院 | 2024-02-27 | — | — | CN | claimed |
| CN-117305184-A | Serratia marcescens YXNU08 for preventing and treating tobacco bacterial wilt and application thereof | 玉溪师范学院 | 2023-12-29 | — | — | CN | claimed |
| EP-3727436-B1 | COMPOSITION FOR TREATING EHLERS DANLOS SYNDROME | RESOLYS BIO INC (US) | 2023-11-15 | — | — | EP | claimed |
| EP-4210505-A2 | FOOD SUPPLEMENT OR MEDICINAL OR PHARMACEUTICAL COMPOSITION INHIBITING VIRUS INFECTION, ADVANTAGEOUSLY INFECTION OF SARS-COV-2 AND IBV CORONAVIRUSES AND FORMULATION THEREOF | Gyulai László (HU) | 2023-07-19 | — | — | EP | claimed |
| EP-4204085-A1 | COMPOSITION FOR USE IN TREATING HEPATIC DISEASES | Biologische Heilmittel Heel GmbH (DE) | 2023-07-05 | — | — | EP | claimed |
| WO-2022112806-A2 | FOOD SUPPLEMENT OR MEDICINAL OR PHARMACEUTICAL COMPOSITION INHIBITING VIRUS INFECTION, ADVANTAGEOUSLY INFECTION OF SARS-COV-2 AND IBV CORONAVIRUSES AND FORMULATION THEREOF | GYULAI LASZLO (HU) | 2022-06-02 | — | — | WO | claimed |
| WO-2022043479-A1 | COMPOSITION FOR USE IN TREATING HEPATIC DISEASES | BIOLOGISCHE HEILMITTEL HEEL GMBH (DE) | 2022-03-03 | — | — | WO | claimed |
| CN-109158081-A | A kind of air purifying preparation | 四川建源节能科技有限公司 | 2019-01-08 | — | — | CN | claimed |
| US-7163941-B2 | Pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2007-01-16 | — | — | US | claimed |
| US-20060247210-A1 | such as (4-Benzothiazol-2-yl-1H-pyrazol-3-yl)-[2-(1H-imidazol-4-yl)-ethyl]-amine, used in the treatment of disorders associated with hyperproliferation and tissue remodelling or repair, inflammation, cell migration and invasion, and renal diseases, or as protein kinase inhibitors | QLT INC. (CA) | 2006-11-02 | — | — | US | claimed |
| EP-1615921-A2 | PYRIDO 2,3-D PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-18 | — | — | EP | claimed |
| US-6967216-B2 | Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor | ASTRAZENECA AB (SE) | 2005-11-22 | — | — | US | claimed |
| US-20050130984-A1 | Pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents | F. HOFFMANN-LA ROCHE AG (DE) | 2005-06-16 | — | — | US | claimed |
| CN-1578771-A | Developer components and their use for dyeing keratinic fibers | HENKEL KGAA (DE) | 2005-02-09 | — | — | CN | claimed |
| WO-2004085436-A2 | PYRIDO[2,3-D]PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-10-07 | — | — | WO | claimed |
| US-20030225097-A1 | Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by np y5 receptor | ASTRAZENECA AB (SE) | 2003-12-04 | — | — | US | claimed |
| EP-1278739-A1 | AMINO SUBSTITUTED DIBENZOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE NP Y5 RECEPTOR | AstraZeneca AB (SE) | 2003-01-29 | — | — | EP | claimed |
| WO-2001085714-A1 | AMINO SUBSTITUTED DIBENZOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE NP Y5 RECEPTOR | ASTRAZENECA AB (SE) | 2001-11-15 | — | — | WO | claimed |