Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TNF | P01375 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2886689 | 0.93 | HRH3 (0.57) | HRH3CYP11B1CYP11B2HTTSMN1; SMN2 | |
| SCHEMBL2891615 | 0.82 | BACE1 (0.42) | HRH3CYP11B1CYP11B2HTTSMN1; SMN2 | |
| SCHEMBL2883537 | 0.81 | HRH3 (0.57) | HRH3CYP11B1CYP11B2HTTSMN1; SMN2 | |
| SCHEMBL2884414 | 0.80 | HRH3 (0.56) | HRH3CYP11B1CYP11B2HTTSMN1; SMN2 | |
| SCHEMBL2881480 | 0.78 | HRH3 (0.60) | HRH3CYP11B1CYP11B2HTTSMN1; SMN2 | |
| SCHEMBL7498825 | 0.73 | CHRM4 (0.55) | ALDH1A1 | |
| SCHEMBL7498815 | 0.73 | CHRM4 (0.55) | ALDH1A1 | |
| SCHEMBL2891618 | 0.73 | CYP11B1 (0.45) | HRH3CYP11B1CYP11B2HTTSMN1; SMN2 | |
| SCHEMBL4943536 | 0.70 | HRH3 (0.78) | HRH3 | |
| SCHEMBL3726320 | 0.70 | HRH3 (0.78) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820825-B2 | N-substituted-azacyclylamines as histamine-3 antagonists | WYETH LLC (US) | 2010-10-26 | — | — | US | claimed |