Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.60 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TNF | P01375 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2886689 | 0.86 | HRH3 (0.57) | HRH3CYP11B1CYP11B2ALDH1A1TNF | |
| SCHEMBL1813650 | 0.85 | HRH3 (0.46) | HRH3CYP11B1CYP11B2ALDH1A1HTT | |
| SCHEMBL2886483 | 0.81 | HRH3 (0.81) | HRH3CYP11B1CYP11B2ALDH1A1IDO1 | |
| SCHEMBL2881324 | 0.80 | HRH3 (0.52) | HRH3CYP11B1CYP11B2ALDH1A1HTT | |
| SCHEMBL2886675 | 0.80 | HRH3 (0.52) | HRH3ALDH1A1 | |
| SCHEMBL2883883 | 0.80 | HRH3 (0.52) | HRH3 | |
| SCHEMBL2884425 | 0.78 | HRH3 (0.49) | HRH3CYP11B1CYP11B2ALDH1A1TNF | |
| SCHEMBL3177643 | 0.78 | CYP11B1 (0.80) | CYP11B1CYP11B2ALDH1A1TNFHTT | |
| SCHEMBL31722842 | 0.78 | CYP11B1 (0.80) | CYP11B1CYP11B2ALDH1A1TNFHTT | |
| SCHEMBL2880209 | 0.77 | HRH3 (0.49) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820825-B2 | N-substituted-azacyclylamines as histamine-3 antagonists | WYETH LLC (US) | 2010-10-26 | — | — | US | disclosed |