SCHEMBL28844264

SCHEMBL28844264

Fc1cc(-c2ccc[nH]2)cc(F)c1F

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
CDK2 P24941 9/20 0.36
CNR1 P21554 1/20 0.33
AR P10275 1/20 0.33
AKR1C3 P42330 1/20 0.33
CHEK1 O14757 1/20 0.32
NT5E P21589 1/20 0.32
CSF1R P07333 1/20 0.32
KDM4C Q9H3R0 1/20 0.32
NOTUM Q6P988 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25438695 0.82 NOTUM (0.47) HDAC1HDAC6CDK2CNR1CHEK1
SCHEMBL18821909 0.81 HDAC6 (0.45) HDAC1HDAC6CNR1CHEK1NT5E
SCHEMBL25439308 0.81 NOTUM (0.48) HDAC1HDAC6CDK2CNR1CHEK1
SCHEMBL28218498 0.78 CDK2 (0.39) CDK2
SCHEMBL9419852 0.73 HDAC6 (0.57) HDAC1HDAC6CNR1CHEK1NT5E
SCHEMBL9302892 0.73 HDAC1 (0.48) HDAC1HDAC6
SCHEMBL15416935 0.73 CDK2 (0.44) CDK2
SCHEMBL24727884 0.73 HDAC1 (0.42) HDAC1HDAC6CDK2CNR1
SCHEMBL30460063 0.72 IDO1 (0.55) CDK2CNR1NOTUM
SCHEMBL28167638 0.72 IDO1 (0.55) CDK2CNR1NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106654032-A Monolayer full-phosphorescence white-light organic electroluminescent device and preparation method thereof 苏州大学 2017-05-10 CN claimed