Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1SLC9A3
The experimentally established mechanism targets of L-Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Lactic Acid SCHEMBL28334583 | 1.00 | TP53 (0.38) | TP53CA2CA4CA1 | |
| L-Lactic Acid SCHEMBL6394826 | 0.97 | TP53 (0.40) | TP53CA2CA4CA1 | |
| L-Lactic Acid SCHEMBL3446641 | 0.97 | TP53 (0.40) | TP53CA2CA4CA1 | |
| L-Lactic Acid SCHEMBL28085882 | 0.94 | TP53 (0.38) | TP53CA2CA4CA1 | |
| L-Lactic Acid SCHEMBL17181715 | 0.92 | TP53 (0.40) | TP53CA2CA4CA1 | |
| L-Lactic Acid SCHEMBL20591059 | 0.92 | TP53 (0.40) | TP53CA2CA4CA1 | |
| L-Lactic Acid SCHEMBL17181713 | 0.92 | TP53 (0.40) | TP53CA2CA4CA1 | |
| L-Lactic Acid SCHEMBL9420938 | 0.92 | TP53 (0.40) | TP53CA2CA4CA1 | |
| L-Lactic Acid SCHEMBL21734203 | 0.92 | TP53 (0.40) | TP53CA2CA4CA1 | |
| L-Lactic Acid SCHEMBL21734205 | 0.92 | TP53 (0.40) | TP53CA2CA4CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107709315-A | The inhibitor of bruton's tyrosine kinase | 药品循环有限责任公司 | 2018-02-16 | — | — | CN | disclosed |
| CN-106999495-A | Combination of TLR inhibitor and bruton's tyrosine kinase inhibitor | 药品循环有限责任公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-106999494-A | Inhibitors of bruton's tyrosine kinase | 药品循环有限公司 | 2017-08-01 | — | — | CN | disclosed |