SCHEMBL2884479

SCHEMBL2884479

O=C(O)OC(C(F)(F)F)C(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA9 Q16790 1/20 0.35
ABHD6 Q9BV23 11/20 0.34
MGLL Q99685 3/20 0.32
PLA2G7 Q13093 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28527974 0.97 ABHD6 (0.33) CA1CA2CA9ABHD6MGLL
SCHEMBL21051130 0.79
SCHEMBL15824292 0.79 CA1 (0.36) CA1CA2CA9ABHD6MGLL
SCHEMBL719545 0.79 CA1 (0.36) CA1CA2CA9ABHD6MGLL
SCHEMBL28970964 0.78
SCHEMBL6278994 0.78 ABHD6 (0.33) CA1CA2CA9ABHD6MGLL
SCHEMBL30610079 0.77 CA1 (0.35) CA1CA2CA9ABHD6MGLL
SCHEMBL22062183 0.76 ABHD6 (0.35) CA1CA2CA9ABHD6MGLL
SCHEMBL28963802 0.76 NPC1 (0.32)
SCHEMBL11741427 0.74 ABHD6 (0.33) CA1CA2CA9ABHD6MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112469473-A Heterocyclic spiro compounds as MAGL inhibitors 辉瑞公司 2021-03-09 CN disclosed
EP-1836235-B1 POLYCARBONATES WITH FLUOROALKYLENE CARBONATE END GROUPS SABIC INNOVATIVE PLASTICS IP (NL) 2010-11-17 EP disclosed
US-7687557-B2 Polycarbonates with fluoroalkylene carbonate end groups SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2010-03-30 US disclosed
US-20080108777-A1 POLYCARBONATES WITH FLUOROALKYLENE CARBONATE END GROUPS GENERAL ELECTRIC COMPANY (US) 2008-05-08 US disclosed
CN-101087828-A Polycarbonates with fluoroalkylene carbonate end groups GEN ELECTRIC (US) 2007-12-12 CN disclosed
EP-1836235-A1 POLYCARBONATES WITH FLUOROALKYLENE CARBONATE END GROUPS General Electric Company (US) 2007-09-26 EP disclosed
WO-2006068818-A1 POLYCARBONATES WITH FLUOROALKYLENE CARBONATE END GROUPS GENERAL ELECTRIC COMPANY (US) 2006-06-29 WO disclosed
US-20060135737-A1 Polycarbonates with fluoroalkylene carbonate end groups CITIBANK, N.A., AS COLLATERAL AGENT 2006-06-22 US disclosed
US-20060135662-A1 Polycarbonates with fluoroalkylene carbonate end groups GENERAL ELECTRIC COMPANY (US) 2006-06-22 US disclosed