Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28844618 | 0.84 | MAPT (0.44) | MAPTGPR35GAALMNAABCB1 | |
| SCHEMBL30396358 | 0.84 | ABCB1 (0.45) | MAPTGPR35GAALMNAABCB1 | |
| SCHEMBL19332557 | 0.83 | MAPT (0.52) | MAPTGAALMNAMEN1KMT2A | |
| SCHEMBL2768155 | 0.83 | MAPT (0.52) | MAPTGAALMNAMEN1KMT2A | |
| SCHEMBL29865413 | 0.82 | MAPT (0.44) | MAPTGPR35GAALMNAABCB1 | |
| SCHEMBL5356936 | 0.81 | MAPT (0.47) | MAPTGAALMNAABCB1MEN1 | |
| SCHEMBL5356932 | 0.81 | MAPT (0.47) | MAPTGAALMNAABCB1MEN1 | |
| SCHEMBL22760104 | 0.81 | ABCB1 (0.42) | MAPTGPR35GAALMNAABCB1 | |
| SCHEMBL215256 | 0.81 | MAPT (0.43) | MAPTGPR35GAALMNAMEN1 | |
| SCHEMBL2735962 | 0.81 | MAPT (0.43) | MAPTGPR35GAALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110483366-B | Indole compound and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-09-16 | — | — | CN | disclosed |