SCHEMBL28844864

SCHEMBL28844864

COCCOc1ccc(Cl)cc1NC(=O)Cc1cccc(Cl)c1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KCNQ2 O43526 4/20 0.53
LMNA P02545 2/20 0.53
KMT2A Q03164 5/20 0.52
MEN1 O00255 4/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
IRAK4 Q9NWZ3 1/20 0.51
ALDH1A1 P00352 4/20 0.49
L3MBTL1 Q9Y468 2/20 0.47
HSD17B10 Q99714 2/20 0.47
TSHR P16473 1/20 0.47
POLB P06746 1/20 0.47
KDM4E B2RXH2 1/20 0.46
USP2 O75604 1/20 0.46
MAPT P10636 1/20 0.46
HPGD P15428 1/20 0.46
ANO1 Q5XXA6 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29732928 1.00 KCNQ2 (0.53) KCNQ2LMNAKMT2AMEN1SMN1; SMN2
SCHEMBL29732958 1.00 KCNQ2 (0.53) KCNQ2LMNAKMT2AMEN1SMN1; SMN2
SCHEMBL29732903 0.92 LMNA (0.59) LMNAKMT2AMEN1SMN1; SMN2IRAK4
SCHEMBL28844846 0.92 LMNA (0.59) LMNAKMT2AMEN1SMN1; SMN2IRAK4
SCHEMBL29733013 0.89 MEN1 (0.57) LMNAKMT2AMEN1SMN1; SMN2IRAK4
SCHEMBL28844878 0.89 MEN1 (0.57) LMNAKMT2AMEN1SMN1; SMN2IRAK4
SCHEMBL29733069 0.86 MEN1 (0.53) LMNAKMT2AMEN1SMN1; SMN2IRAK4
SCHEMBL28844866 0.86 MEN1 (0.53) LMNAKMT2AMEN1SMN1; SMN2IRAK4
SCHEMBL29732943 0.85 KMT2A (0.54) LMNAKMT2AMEN1SMN1; SMN2IRAK4
SCHEMBL29732762 0.85 KMT2A (0.52) LMNAKMT2AMEN1SMN1; SMN2IRAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114763347-B Compound for inducing mesenchymal stem cells to differentiate into cartilage and application thereof 华东师范大学 2024-06-21 CN claimed
CN-114763347-A Compound for inducing mesenchymal stem cells to differentiate towards cartilage and application thereof 华东师范大学 2022-07-19 CN claimed
CN-114763347-B Compound for inducing mesenchymal stem cells to differentiate into cartilage and application thereof 华东师范大学 2024-06-21 CN disclosed
CN-114763347-A Compound for inducing mesenchymal stem cells to differentiate towards cartilage and application thereof 华东师范大学 2022-07-19 CN disclosed