SCHEMBL28844945

SCHEMBL28844945

COCCOc1ccc(Cl)cc1NC(=O)Cc1ccc(F)cc1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.52
MEN1 O00255 6/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
ALDH1A1 P00352 3/20 0.49
MAPT P10636 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.48
IRAK4 Q9NWZ3 1/20 0.48
LMNA P02545 1/20 0.47
THRB P10828 1/20 0.47
POLB P06746 1/20 0.46
KDM4E B2RXH2 1/20 0.46
HTT P42858 1/20 0.46
CCR3 P51677 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29732762 1.00 KMT2A (0.52) KMT2AMEN1L3MBTL1ALDH1A1MAPT
SCHEMBL28844878 0.93 MEN1 (0.57) KMT2AMEN1L3MBTL1ALDH1A1MAPT
SCHEMBL29733013 0.93 MEN1 (0.57) KMT2AMEN1L3MBTL1ALDH1A1MAPT
SCHEMBL29733069 0.90 MEN1 (0.53) KMT2AMEN1L3MBTL1ALDH1A1MAPT
SCHEMBL28844866 0.90 MEN1 (0.53) KMT2AMEN1L3MBTL1ALDH1A1MAPT
SCHEMBL29732943 0.89 KMT2A (0.54) KMT2AMEN1L3MBTL1ALDH1A1MAPT
SCHEMBL28844881 0.89 KMT2A (0.54) KMT2AMEN1L3MBTL1ALDH1A1MAPT
SCHEMBL29732903 0.88 LMNA (0.59) KMT2AMEN1L3MBTL1ALDH1A1SMN1; SMN2
SCHEMBL28844846 0.88 LMNA (0.59) KMT2AMEN1L3MBTL1ALDH1A1SMN1; SMN2
SCHEMBL29732928 0.85 KCNQ2 (0.53) KMT2AMEN1L3MBTL1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114763347-B Compound for inducing mesenchymal stem cells to differentiate into cartilage and application thereof 华东师范大学 2024-06-21 CN claimed
CN-114763347-B Compound for inducing mesenchymal stem cells to differentiate into cartilage and application thereof 华东师范大学 2024-06-21 CN disclosed
CN-114763347-A Compound for inducing mesenchymal stem cells to differentiate towards cartilage and application thereof 华东师范大学 2022-07-19 CN disclosed