Pyrimidine

Pyrimidine

SCHEMBL28845102

NC(N)=O.[NaH].c1cncnc1

nearest known ligand 0.41

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F7 P08709 1/20 0.41
F3 P13726 1/20 0.41
SARM1 Q6SZW1 1/20 0.41
SIRT2 Q8IXJ6 1/20 0.41
SIRT6 Q8N6T7 1/20 0.41
SIRT1 Q96EB6 1/20 0.41
SIRT3 Q9NTG7 1/20 0.41
SIRT5 Q9NXA8 1/20 0.41
SIRT4 Q9Y6E7 1/20 0.41
ALDH1A1 P00352 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
LMNA P02545 1/20 0.38
OR51E2 Q9H255 1/20 0.38
MKNK1 Q9BUB5 2/20 0.34
MKNK2 Q9HBH9 2/20 0.34
RECQL P46063 1/20 0.33
P2RX7 Q99572 1/20 0.32
HCAR2 Q8TDS4 2/20 0.32
TSHR P16473 2/20 0.32
APP P05067 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrimidine SCHEMBL374258 0.97 F7 (0.42) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL28421059 0.97 F7 (0.42) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL28248566 0.94 F7 (0.41) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL28103116 0.94 F7 (0.41) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL28251830 0.94 F7 (0.41) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL28121327 0.94 F7 (0.41) F7F3SARM1SIRT2SIRT6
Pyridine SCHEMBL28266547 0.88 NAPRT (0.50) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL28643613 0.88 F7 (0.46) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL1150634 0.88 F7 (0.46) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL28229655 0.86 SIRT3 (0.37) F7F3SARM1SIRT2SIRT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114933587-A Preparation method of trifloxysulfuron sodium salt 江苏省农用激素工程技术研究中心有限公司 2022-08-23 CN disclosed