Pyrimidine

Pyrimidine

SCHEMBL374258

NC(N)=O.c1cncnc1

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F7 P08709 1/20 0.42
F3 P13726 1/20 0.42
SARM1 Q6SZW1 1/20 0.42
SIRT2 Q8IXJ6 1/20 0.42
SIRT6 Q8N6T7 1/20 0.42
SIRT1 Q96EB6 1/20 0.42
SIRT3 Q9NTG7 1/20 0.42
SIRT5 Q9NXA8 1/20 0.42
SIRT4 Q9Y6E7 1/20 0.42
ALDH1A1 P00352 2/20 0.40
TDP1 Q9NUW8 2/20 0.40
LMNA P02545 1/20 0.40
OR51E2 Q9H255 1/20 0.40
MKNK1 Q9BUB5 3/20 0.35
MKNK2 Q9HBH9 3/20 0.35
RECQL P46063 1/20 0.34
HCAR2 Q8TDS4 2/20 0.33
TSHR P16473 2/20 0.33
P2RX7 Q99572 1/20 0.33
APP P05067 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrimidine SCHEMBL28421059 1.00 F7 (0.42) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL28845102 0.97 F7 (0.41) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL28248566 0.97 F7 (0.41) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL28103116 0.97 F7 (0.41) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL28121327 0.97 F7 (0.41) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL28251830 0.97 F7 (0.41) F7F3SARM1SIRT2SIRT6
Pyridine SCHEMBL28266547 0.91 NAPRT (0.50) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL28643613 0.90 F7 (0.46) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL1150634 0.90 F7 (0.46) F7F3SARM1SIRT2SIRT6
Pyrimidine SCHEMBL28229655 0.89 SIRT3 (0.37) F7F3SARM1SIRT2SIRT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 308 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113880823-A Method for preparing isoxazoline-containing urea pyrimidine compound intermediate 沈阳中化农药化工研发有限公司 2022-01-04 CN claimed
CN-108896694-B A kind of remaining LC-QToF-MS Screening analysis method of pesticide in animal food 中国农业科学院农业质量标准与检测技术研究所 2019-09-27 CN claimed
CN-110204547-A Synthesis method of 1, 3-dimethyl uric acid 绍兴市精益生物化工有限公司 2019-09-06 CN claimed
CN-109755573-A Oligomer macromolecule and lithium battery 王復民 2019-05-14 CN claimed
CN-106633053-B The preparation and application of cyanurate-urea pyrimidine copolymer zinc salt novel PVC stabilizer 深圳市志海实业股份有限公司 2019-05-10 CN claimed
CN-109721549-A A kind of urea pyrimidine schiff bases and its preparation method and application 衢州建华东旭助剂有限公司 2019-05-07 CN claimed
CN-105670979-B Nucleoside phosphorylase, coding gene, high-yield strain thereof and application 南京工业大学 2019-03-26 CN claimed
CN-109384730-A 1- { 3- [p- double-(2- chloroethyl) amido] phenylpropyl alcohol amido } formyl -5-fluor-uracil and preparation and application 南京友怡医药科技有限公司 2019-02-26 CN claimed
CN-109206374-A Tetraphenyl ethylene isomer with aggregation-induced emission and supramolecular polymerization properties and preparation method and application thereof 香港科技大学 2019-01-15 CN claimed
CN-109046419-A A kind of ginkgo leaf base porous carbon materials and its preparation method and application loading ruthenium 桂林电子科技大学 2018-12-21 CN claimed
CN-106478990-A A kind of novel melting one-step method prepares hydroxy fatty acid calcium zinc PVC stabilizer 深圳市志海实业股份有限公司 2017-03-08 CN claimed
CN-103068834-B Phosphoramidites for reverse RNA synthesis 坎姆根公司 2016-10-26 CN claimed
CN-105418592-A Substituted pyrimidine compounds and application thereof UNIV EAST CHINA SCIENCE & TECH 2016-03-23 CN claimed
CN-101111462-B Process for production of fluoro derivative CENTRAL GLASS CO.,LTD. (JP) 2011-12-28 CN claimed
CN-101346474-A Selectable nucleotides for improved targeted nucleotide exchange KEYGENE NV (NL) 2009-01-14 CN claimed
CN-101111462-A Process for production of fluoro derivative CENTRAL GLASS CO LTD (JP) 2008-01-23 CN claimed
CN-1169796-C Catalytic synthesis process of methyl substituted pyrimidyl urea derivative 中国科学院大连化学物理研究所 2004-10-06 CN claimed
CN-1403446-A Catalytic synthesis process of methyl substituted pyrimidyl urea derivative DALIAN CHEMICAL PHYSICS INST (CN) 2003-03-19 CN claimed
CN-1060781-C Phosphonootropic monoester nucleic acids, process for their preparation and their use HOECHST AG (DE) 2001-01-17 CN claimed
CN-1138588-A Phosphonootropic monoester nucleic acids, process for their preparation and their use HOECHST AG (DE) 1996-12-25 CN claimed