Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17390278 | 0.80 | TSHR (0.37) | TSHRSLC1A3SLC1A2SLC1A1CHRM2 | |
| SCHEMBL28718690 | 0.77 | TSHR (0.33) | TSHRSLC1A3SLC1A2SLC1A1CHRM2 | |
| SCHEMBL20123340 | 0.72 | ALOX15 (0.42) | TSHRCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL28529454 | 0.69 | GRIK1 (0.33) | TSHRCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL28529455 | 0.69 | GRIK1 (0.33) | TSHRCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3294916 | 0.69 | SLC1A1 (0.48) | TSHRSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL22506805 | 0.69 | SLC1A1 (0.48) | TSHRSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL28513037 | 0.69 | TSHR (0.40) | TSHRSLC1A3SLC1A2SLC1A1CHRM2 | |
| SCHEMBL15800542 | 0.69 | SLC1A3 (0.33) | TSHRSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL13816292 | 0.69 | CYP1A2 (0.42) | TSHRCHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117677399-A | Effective ASGPR binding compounds for the degradation of immunoglobulins and other proteins | 阿维拉治疗公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-115335081-A | Targeted plasma protein degradation | 诺华股份有限公司 | 2022-11-11 | — | — | CN | disclosed |
| CN-115066438-A | ASGPR binding compounds for degrading extracellular proteins | 阿维拉治疗公司 | 2022-09-16 | — | — | CN | disclosed |