Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30761115 | 1.00 | IRAK4 (0.45) | IRAK4HCRTR1LMNAKMT2AKDM4E | |
| SCHEMBL17007232 | 0.85 | MYC (0.55) | HCRTR1LMNAKMT2AKDM4EMEN1 | |
| SCHEMBL21988904 | 0.84 | HCRTR1 (0.44) | HCRTR1LMNAKMT2AKDM4EMEN1 | |
| SCHEMBL18039131 | 0.79 | HCRTR1 (0.44) | IRAK4HCRTR1KDM4EALDH1A1MAPT | |
| SCHEMBL945426 | 0.78 | CYP2A6 (0.41) | IRAK4HCRTR1LMNAKMT2AKDM4E | |
| SCHEMBL312316 | 0.78 | GAA (0.43) | IRAK4LMNAKDM4EALDH1A1GAA | |
| SCHEMBL14938379 | 0.78 | HCRTR1 (0.44) | IRAK4HCRTR1KDM4EALDH1A1MAPT | |
| SCHEMBL28102316 | 0.78 | HCRTR1 (0.41) | HCRTR1LMNAKMT2AKDM4EMEN1 | |
| SCHEMBL21722361 | 0.77 | HCRTR2 (0.44) | IRAK4HCRTR1LMNAKMT2AKDM4E | |
| SCHEMBL3544059 | 0.77 | NPC1 (0.49) | IRAK4HCRTR1LMNAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658639-A | Alkynyl alcohols and methods of use | 豪夫迈·罗氏有限公司 | 2016-06-08 | — | — | CN | disclosed |
| US-20100261699-A1 | N-PYRAZOLE-2-PYRIDINE CARBOXAMIDE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. | 2010-10-14 | — | — | US | disclosed |
| EP-2236507-A1 | N-PYRAZOLE-2-PYRIDINECARBOXAMIDE DERIVATIVE | Banyu Pharmaceutical Co., Ltd. (JP) | 2010-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261699-A1 | N-PYRAZOLE-2-PYRIDINE CARBOXAMIDE DERIVATIVE | GCKR, GPR119, GCK | IRAK4 467/4885HCRTR1 1634/4885LMNA 3929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.