Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | WDR5 | P61964 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4289177 | 0.90 | WDR5 (0.69) | MAPTALDH1A1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL29891470 | 0.87 | MAPT (0.59) | MAPTALDH1A1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL29892052 | 0.86 | WDR5 (0.62) | MAPTALDH1A1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL29891273 | 0.84 | WDR5 (0.54) | MAPTALDH1A1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL29891093 | 0.84 | WDR5 (0.59) | MAPTALDH1A1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL23292304 | 0.83 | WDR5 (0.62) | MAPTALDH1A1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL29994410 | 0.83 | WDR5 (0.62) | MAPTALDH1A1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL28845856 | 0.81 | SMN1; SMN2 (0.61) | MAPTALDH1A1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL29891443 | 0.81 | KDM4E (0.62) | MAPTALDH1A1KDM4EHPGDWDR5 | |
| SCHEMBL1657077 | 0.80 | SMN1; SMN2 (0.64) | MAPTALDH1A1KDM4ECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109734674-B | Aniline WDR5 protein-protein interaction inhibitor and preparation method and application thereof | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |