Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HEXA | P06865 | 1/20 | 0.46 |
| ▸ | HEXB | P07686 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 2/20 | 0.45 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28171296 | 0.86 | AKT2 (0.61) | KDM4EALDH1A1IKBKBMAP3K14MAPK1 | |
| SCHEMBL13312276 | 0.82 | IKBKB (0.67) | KDM4EDYRK1AGAAALDH1A1IKBKB | |
| SCHEMBL17731310 | 0.77 | HTT (0.48) | KDM4EDYRK1AMAPTRAB9AGAA | |
| SCHEMBL8034982 | 0.75 | HTT (0.56) | KDM4EDYRK1AMAPTRAB9AGAA | |
| SCHEMBL13516427 | 0.74 | MAPT (0.50) | KDM4EDYRK1AMAPTRAB9AGAA | |
| SCHEMBL28067319 | 0.74 | MAPT (0.50) | KDM4EDYRK1AMAPTRAB9AGAA | |
| SCHEMBL8097613 | 0.72 | TDP1 (0.56) | KDM4EDYRK1AMAPTRAB9AALDH1A1 | |
| SCHEMBL3364101 | 0.71 | JAK2 (0.66) | DYRK1ACHUK | |
| SCHEMBL12907168 | 0.71 | PRKAG1 (0.68) | DYRK1A | |
| SCHEMBL4898151 | 0.71 | KDM4E (0.51) | KDM4EDYRK1AMAPTRAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108638-A | Piperidyl PyrazolopyrimidinonecGMP and application thereof | 拜耳制药股份公司 | 2017-08-29 | — | — | CN | disclosed |