SCHEMBL28850071

SCHEMBL28850071

CC(C)(C)OC(=O)N1CCC(Oc2nc(Cl)cc(Cl)c2O)C1

nearest known ligand 0.52

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 19/20 0.52
PIK3CA P42336 2/20 0.47
PIK3CB P42338 2/20 0.47
PIK3CG P48736 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23608592 1.00 PIK3CD (0.52) PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL23580125 0.87 PIK3CD (0.50) PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL28849977 0.87 PIK3CD (0.50) PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL23580127 0.87 PIK3CD (0.50) PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL23608593 0.87 PIK3CD (0.50) PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL28850143 0.85 PIK3CD (0.48) PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL29882399 0.85 PIK3CD (0.48) PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL29882611 0.85 PIK3CD (0.48) PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL27020528 0.85 PIK3CD (0.48) PIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL23581035 0.84 SPR (0.39) PIK3CDPIK3CAPIK3CBPIK3CG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114945571-A Cyclic compounds and methods of use thereof 薛定谔公司 2022-08-26 CN disclosed