Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.34 |
| ▸ | JAK3 | P52333 | 8/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29950563 | 0.73 | JAK3 (0.33) | JAK2JAK3JAK1RET | |
| SCHEMBL28850992 | 0.72 | JAK3 (0.33) | JAK2JAK3JAK1RET | |
| SCHEMBL22325300 | 0.72 | JAK3 (0.33) | JAK2JAK3JAK1RET | |
| SCHEMBL29950366 | 0.72 | JAK3 (0.33) | JAK2JAK3JAK1RET | |
| SCHEMBL22325258 | 0.72 | JAK2 (0.58) | JAK2JAK3JAK1RET | |
| SCHEMBL22325257 | 0.72 | JAK2 (0.58) | JAK2JAK3JAK1RET | |
| SCHEMBL22343519 | 0.70 | JAK3 (0.41) | JAK2JAK3JAK1 | |
| Phosphoric Acid SCHEMBL28725937 | 0.69 | JAK2 (0.55) | JAK2JAK3JAK1RET | |
| SCHEMBL24599487 | 0.68 | — | — | |
| SCHEMBL24599456 | 0.67 | JAK2 (0.40) | JAK2JAK3JAK1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115141180-B | Preparation method of ruxotinib intermediate | 济宁学院 | 2023-06-20 | — | — | CN | disclosed |
| CN-115141180-A | Preparation method of ruxotinib intermediate | 济宁学院 | 2022-10-04 | — | — | CN | disclosed |