Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.33 |
| ▸ | JAK2 | O60674 | 17/20 | 0.33 |
| ▸ | JAK1 | P23458 | 10/20 | 0.33 |
| ▸ | TYK2 | P29597 | 5/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.32 |
| ▸ | PAK4 | O96013 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | LTK | P29376 | 2/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.32 |
| ▸ | CLK2 | P49760 | 2/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.32 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29950366 | 0.83 | JAK3 (0.33) | JAK3JAK2JAK1TYK2DAPK3 | |
| SCHEMBL28850992 | 0.83 | JAK3 (0.33) | JAK3JAK2JAK1TYK2DAPK3 | |
| SCHEMBL22325300 | 0.83 | JAK3 (0.33) | JAK3JAK2JAK1TYK2DAPK3 | |
| SCHEMBL22343495 | 0.78 | JAK3 (0.34) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL22343519 | 0.76 | JAK3 (0.41) | JAK3JAK2JAK1TYK2LRRK2 | |
| SCHEMBL22325257 | 0.76 | JAK2 (0.58) | JAK3JAK2JAK1TYK2DAPK3 | |
| SCHEMBL22325258 | 0.76 | JAK2 (0.58) | JAK3JAK2JAK1TYK2DAPK3 | |
| SCHEMBL24599487 | 0.75 | — | — | |
| SCHEMBL28850995 | 0.73 | JAK2 (0.34) | JAK3JAK2JAK1RET | |
| SCHEMBL22343556 | 0.73 | JAK3 (0.32) | JAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115141180-B | Preparation method of ruxotinib intermediate | 济宁学院 | 2023-06-20 | — | — | CN | disclosed |
| CN-115141180-A | Preparation method of ruxotinib intermediate | 济宁学院 | 2022-10-04 | — | — | CN | disclosed |