Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.42 |
| ▸ | PDE4A | P27815 | 4/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28189250 | 0.89 | PDE4B (0.39) | PDE4BPDE4APDE4CPDE4DCA1 | |
| SCHEMBL28189206 | 0.89 | PDE4B (0.39) | PDE4BPDE4APDE4CPDE4DCA1 | |
| SCHEMBL28853800 | 0.88 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL28189207 | 0.88 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL28853737 | 0.88 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4371698 | 0.78 | MEN1 (0.44) | MEN1KMT2APOLBGAAF2 | |
| SCHEMBL4366818 | 0.77 | APP (0.40) | MEN1KMT2APOLBGAAF2 | |
| SCHEMBL9938952 | 0.77 | PDE4A (0.48) | PDE4BPDE4APDE4CPDE4DSMPD1 | |
| SCHEMBL4372450 | 0.76 | MEN1 (0.48) | MEN1KMT2AGAAMAPK1APP | |
| SCHEMBL4369067 | 0.75 | APP (0.53) | MEN1KMT2APOLBGAAAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108059635-A | Thiophene derivant | 天津合美医药科技有限公司 | 2018-05-22 | — | — | CN | claimed |
| CN-107964016-A | Thiophene derivant | 天津合美医药科技有限公司 | 2018-04-27 | — | — | CN | claimed |
| CN-107722036-A | Thiophene derivant | 天津合美医药科技有限公司 | 2018-02-23 | — | — | CN | claimed |
| CN-107501290-A | Thiophene derivant | 天津合美医药科技有限公司 | 2017-12-22 | — | — | CN | claimed |
| CN-108059635-A | Thiophene derivant | 天津合美医药科技有限公司 | 2018-05-22 | — | — | CN | disclosed |
| CN-107964016-A | Thiophene derivant | 天津合美医药科技有限公司 | 2018-04-27 | — | — | CN | disclosed |
| CN-107722036-A | Thiophene derivant | 天津合美医药科技有限公司 | 2018-02-23 | — | — | CN | disclosed |
| CN-107501290-A | Thiophene derivant | 天津合美医药科技有限公司 | 2017-12-22 | — | — | CN | disclosed |